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EyePoint Announces 53% Workforce Reduction After Phase 3 LUCIA Trial Misses Primary Endpoint in Wet AMD

EyePoint announced a strategic prioritization plan following topline results from the Phase 3 LUCIA trial of DURAVYU in wet AMD, which did not meet its primary endpoint of non-inferiority despite meeting key secondary endpoints including reduction in treatment burden, supplement-free rates, anatomic control, and safety with redosing. The Board approved a plan to reduce the workforce by approximately 53%, conclude the pivotal Phase 3 wet AMD trials early, and refocus resources on the DURAVYU program in diabetic m...

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Key takeaways

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Key metrics

Cash, cash equivalents and short-term investmentsAs of September 30, 2026 (preliminary)
approximately $118 million
Workforce reductionQ4 2026 - H1 2027
approximately 53%
Estimated aggregate restructuring chargesQ4 2026 - Q3 2027
approximately $9 million
Estimated annualized cost savingsForward-looking
approximately $30 million
Phase 3 wet AMD program status
LUCIA missed primary endpoint; LUGANO and LUCIA trials to be concluded early
Phase 3 DME program (COMO and CAPRI) topline data expected
Q4 2027

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